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Web spironolactone is a prescription drug that reduces swelling from liver disease, nephrotic syndrome, high. Web drug details spironolactone is a diuretic medication. Web learn how to take spironolactone, a medicine that helps control high blood pressure, edema, and heart. Web spironolactone controls high blood pressure, edema, heart failure, and hyperaldosteronism but does not cure these conditions. Diuretics are sometimes called water pills. Web spironolactone is a prescription drug that reduces swelling from liver disease, nephrotic syndrome, high.